(1) Clinical Chemistry, Department of Molecular Medicine and Surgery and Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; (2) Departments of Biomedical Engineering and Medicine, Oregon Health and Science University, Portland, Oregon, USA

(1) Department of Orthopedic Surgery, Roper Hospital and Charleston Orthopedic Associates, Charleston, South Carolina, USA; (2) Orthopaedic University Hospital Mainz, Mainz, Germany; (3) Corporate Department of Medical Affairs, Boehringer Ingelheim GmbH, Ingelheim am Rhein, Germany; (4) Medical Data Services, Boehringer Ingelheim Pharma GmbH & Co. PKG, Ingelheim am Rhein, Germany; (5) Department of Orthopaedics, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden; (6) Division of Vascular Surgery, NorthShore University Health System, Evanston, Illinois, USA

(1) Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; (2) Klinik für Kardiovaskuläre Chirurgie Universitätsklinikum, Düsseldorf, Germany; (3) Klinik für Gefäßchirurgie Universitätsklinikum Düsseldorf, Germany; (4) Institut für Pharmakologie, Ernst-Moritz-Arndt Universität Greifswald, Germany

(1) Centro de Investigaciones Biológicas (CIB), Consejo Superior de Investigaciones Científicas (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain; (2) Hospital Sierrallana, Centro de Referencia HHT, Torrelavega, Cantabria, Spain

(1) F. Hoffmann-La Roche AG, Basel, Switzerland; (2) Roche Products Ltd., Welwyn Garden City, UK

(1) School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia; (2) Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, South Australia, Australia

(1) Institute of Dental Research, Westmead Millennium Institute and Westmead Centre for Oral Health, Sydney, Australia; (2) Faculty of Dentistry, University of Sydney, Sydney, Australia; (3) School of Chemistry, University of New South Wales, Sydney, Australia

(1) University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK

(1) Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

(1) Aston University, School of Life and Health Sciences, Birmingham

(1) ER2UPMC, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, France; (2) Service d’Hématologie Biologique Tenon University Hospital, Assistance Publique Hôpitaux de Paris, France; (3) Research and Development, Diagnostica Stago, Gennevilliers, France; (4) Internal Medicine Department, Referral Centre for Adult Sickle Cell Disease, Tenon University Hospital Assistance Public Hospital of Paris, France; (5) ParCC – Paris Center for Cardiovascular Research Inserm UMRs970, Paris, France; (6) Département Infection et Epidémiologie, Institut Pasteur, Paris, France

(1) Department of Clinical Pharmacology, Nanjing First Hospital Affiliated to Nanjing Medical University, and Nanjing Cardiovascular Hospital, Nanjing, Jiangsu, China; (2) Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, China; (3) Department of Cardiology, Nanjing First Hospital Affiliated to Nanjing Medical University, and Nanjing Cardiovascular Hospital, Nanjing, Jiangsu, China

(1) Deutsches Herzzentrum München, Munich, Germany; (2) Biotronik SE & Co. KG, Erlangen, Germany

(1) Deutsches Herzzentrum der Technischen Universität München, München Germany

(1) Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Niigata, Japan; (2) First Department of Internal Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan

(1) Institute of Cardiology, Catholic University, Rome, Italy; (2) Department of Experimental Medicine, “Sapienza” University of Rome, Italy

(1) Thrombosis Centre Department of Heart and Vessels, AOU-Careggi, Florence, Italy; (2) Department of Medical and Surgical Critical Care University of Florence, Italy; (3) Renal Unit, AOU-Careggi, Florence, Italy; (4) Haemostasis and Thrombosis Centre A O Istituti Ospitalieri di Cremona, Cremona, Italy; (5) Department of Clinical MedicineUniversity of Insubria,Varese, Italy; (6) Department of Angiology and Blood Coagulation "Marino Golinelli", University Hospital S. Orsola-Malpighi, Bologna, Italy

(1) Coagulation Research, Institute for Molecular Medicine and Surgery, Karolinska Institutet & Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden; (2) Haemostasis Department and Haemophilia Centre, Blood Transfusion Institute of Serbia, Belgrade, Serbia; (3) Clinic of Haematology, Clinical Centre of Serbia & Faculty of Medicine, University of Belgrade, Serbia; (4) Coagulation Unit, Haematology Centre, Karolinska University Hospital, Stockholm, Sweden; (5) Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany; (6) Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden

(1) St. Marien Hospital Bonn Venusberg, Department of Internal Medicine, Bonn, Germany; (2) Max-Ratschow Clinic, Department of Angiology, Medizinische Klinik IV, Darmstadt, Germany; (3) Kreiskrankenhaus Langenau, Department of Surgery, Langenau, Germany; (4) Private Practice of Cardiology, Heart Centre Alter Hof, München, Germany; (5) Medizinische Klinik and Poliklinik II, Department of Cardiology, Angiology, and Pneumology, University of Bonn, Bonn, Germany

(1) Department of Internal Medicine, Division of Vascular Medicine, Johann Wolfgang Goethe-University Hospital Frankfurt/Main, Germany; (2) Bayer HealthCare, Wuppertal, Germany

(1) Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; (2) Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; (3) Institutes of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; (4) Information Management Office, Taipei Veterans General Hospital, Taipei, Taiwan; (5) Department of Public Finance, National Chengchi University, Taipei, Taiwan; (6) Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; (7) Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, Taipei, Taiwan

(1) Department of Cardiology, Aarhus University Hospital, Denmark; (2) Faculty of Health Sciences, Aarhus University, Denmark; (3) Department of Clinical Biochemistry, Aarhus University Hospital, Denmark

(1) Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands; (2) Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands; (3) Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; (4) Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands

(1) Laboratory of Molecular and Cellular Pathophysiology, Showa Pharmaceutical University, Machida, Tokyo, Japan; (2) High Technology Research Center, Showa Pharmaceutical University, Machida, Tokyo, Japan

(1) Département de Cardiologie, Hôpital Universitaire Nord, Aix-Marseille University, Marseille, France; (2) INSERM UMRS 608, Faculté de Pharmacie, Marseille, France; (3) Faculté de Médecine, Aix-Marseille University, Marseille, France; (4) Research Unit EA 3279 and Department of Public Health, Marseille, France; (5) Pôle RUSH, Hôpital Timone, Marseille, France; (6) Service de Santé Publique et Information Médicale, Hôpital Universitaire Nord, Faculté de Médecine, Marseille, France; (7) Service de Cardiologie, Hôpital de Martigues, Martigues, France; (8) Service de Cardiologie, Clinique les Fleurs, Ollioules, France; (9) Laboratoire d’Hématologie, Hôpital de la Conception, Marseille, France; (10) URMITE UMR 6236, CNRS-IRD, Faculté de Médecine et de Pharmacie, Marseille, France

(1) INSERM, UMR1098, Besançon Cedex, France; (2) Université de Franche-Comté, Besançon Cedex, France; (3) EFS Bourgogne Franche-Comté, laboratoires d’hémostase, cytologie, plateforme de biomonitoring, Besançon Cedex, France; (4) CHU Besançon, Centre d’Investigation Clinique intégré en Biothérapies, CBT506, Besançon Cedex, France

(1) EA3065 Université Jean Monnet, Saint Etienne, Service de Médecine et Thérapeutique, Unité de Pharmacologie Clinique, CHU Saint-Etienne, France; (2) Hôtel-Dieu de Paris, Université Paris Descartes, Paris, France; (3) Service d'Anesthésie-Réanimation, Hopital Cochin(AP-HP), Université Paris Descartes, Paris, France; (4) Département de Chirurgie Orthopédique, CHRU de Caen, Caen France; (5) Laboratoire d'Hématologie, Université Champagne Ardenne, URCA EA 3801, CHU de Reims, Reims, France; (6) INSERM CIE3, CHU Saint-Etienne, Unité de Pharmacologie Clinique, CHU Saint-Etienne, France; (7) EA3065, Université Jean Monnet, Saint-Etienne, Unité de Pharmacologie Clinique, CHU Saint-Etienne, INSERM CIE3, CHU Saint-Etienne, France

(1) Prof.-Hess-Kinderklinik, Bremen, Germany; (2) Children’s Memorial Hospital, Chicago, Illinois, USA; (3) The Hemophilia Center, Phoenix Children’s Hospital, Phoenix, Arizona, USA; (4) University of Texas Health Science Center-Houston, Houston, Texas, USA; (5) Great Ormond Street Hospital For Children, Haemophilia Centre, London, UK; (6) Baxter Healthcare Corporation, Westlake Village, California, USA; (7) Baxter Innovations GmbH, Vienna, Austria

(1) Institute of Environmental Medicine, Division of Cardiovascular Epidemiology, Karolinska Institutet, Stockholm, Sweden; (2) Department of Molecular Medicine & Surgery, Division of Clinical Chemistry/Coagulation Research, Karolinska Institutet, Stockholm, Sweden; (3) Department of Clinical Sciences, Division of Cardiovascular Medicine, Danderyd Hospital, Stockholm, Sweden

(1) Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden

(1) Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark; (2) University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK

(1) University of Insubria-Ospedale di Circolo, Varese, Italy; (2) University of Rochester Medical Center, Rochester, New York, USA; (3) McMaster University, Hamilton, Ontario, Canada

(1) Department of Cardiothoracic and Vascular Sciences, University of Padua, Italy; (2) Department of Clinical Epidemiology and Technology Assessment, University of Maastricht, the Netherlands; (3) Department of Internal Medicine, Unit of Angiology, S Maria Nuova Hospital, Reggio Emilia, Italy; (4) Department of Clinical and Experimental Medicine, Group of Clinical Epidemiology, University of Padua, Italy; (5) Centre for Vascular Medicine, Academic Medical Centre, University of Amsterdam, the Netherlands

(1) Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy

(1) Center for Molecular and Vascular Biology, University of Leuven, Belgium; (2) Experimental Laboratory Medicine, University of Leuven, Belgium; (3) Department of Internal Medicine, University of Leuven, Belgium; (4) Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Conneticut, USA; (5) Department of Microbiology, University of Chicago, Chicago, Illinois, USA

(1) UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, UK; (2) University College London, Division of Surgery and Interventional Science, Royal Free Hospital, London, UK; (3) Centre for Health and Human Performance, London, UK; (4) King's College Hospital, Denmark Hill, London, UK; (5) Anaesthetic Department, Charing Cross Hospital, Fulham Palace Road, London, UK; (6) Integrative Physiology Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, University Hospital Southampton NHS Foundation Trust, Southampton, UK; (7) Critical Care Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK

(1) Lenox Hill Hospital, New York, New York, USA

(1) Department of Thrombosis Biology, Bristol-Myers Squibb, Pennington, New Jersey, USA; (2) Agennix, Inc., Princeton, , New Jersey, USA; (3) Lexicon Pharmaceuticals, The Woodlands, Texas, USA

(1) Hemostasis and Thrombosis Unit, Division of Adult Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; (2) Hemostasis and Thrombosis Laboratory, Division of Biological Chemistry, Cliniques Universitaires Saint-Luc, Brussels, Belgium

(1) Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Italy; (2) Clinic of Orthopaedics and Traumatology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

(1) Institut für Pharmakoökonomie und Arzneimittellogistik (IPAM), Hochschule Wismar, Germany; (2) Boehringer Ingelheim Pharma GmbH & Co.KG, Ingelheim, Germany; (3) Wissenschaftliches Institut der TK für Nutzen und Effizienz im Gesundheitswesen (WINEG), Techniker Krankenkasse, Hamburg, Germany; (4) AOK Plus, Dresden, Germany; (5) Institut für Community Medicine, Abteilung Methoden, Universität Greifswald, Germany; (6) Department of Cardiology and Angiology, Universität Münster, Germany; (7) Department of Vascular Medicine, Klinikum Darmstadt GmbH, Darmstadt, Germany

(1) Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Stockholm, Sweden

(1) John Paul II Hospital, Krakow, Poland; (2) Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland

(1) King's College Hospital, London, UK

(1) Department of Internal Medicine III / Cardiology, Innsbruck Medical University, Austria; (2) Department of Cardiology, King´s College London, UK