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Computer Simulation of Hemo-dynamic Parameter Changes by Mechanical Ventilation and Biventricular Circulatory Support
M. Darowski (1) , C. De Lazzari (2) , G. Ferrari (2) , F. Clemente (2) , M. Guaragno (2)
(1) Institute of Biocybernetics and Biomedical Engineering PAN, Warsaw, Poland, (2) CNR, Istituto di Tecnologie Biomediche, Rome, Italy
Summary
When a Bi-Ventricular Assist Device (BVAD) is used in conjunction with mechanical ventilation (MV) of the lungs with positive intrathoracic pressure (Pt), the latter influences hemodynamics. The aim of our study was to assess the simultaneous influence of BVAD and MV on hemodynamics. We assumed ventricular pathological conditions as reduced elastances and increased rest volumes. Peripheral systemic arterial resistance was assumed to have different values. Data were obtained by computer simulation. Trends in main hemodynamic variables were compared with clinical data from literature. Simulation showed that systemic venous, pulmonary arterial and left atrial pressures are very sensitive to Pt (-2 to 5 mmHg).
Keywords
Computer Simulation, Biventricular Assist Device, Mechanical Ventilation, Hemodynamics
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C. De Lazzari(1) , M. Darowski (2) , P. Wolski (3) , G. Ferrari(1) , G. Tosti(1) , D. M. Pisanelli(4) Methods of Information in Medicine 2005 44 1: 98-105 | ||
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C. De Lazzari (1), D. Neglia (2), G. Ferrari (1), F. Bernini (2), M. Micalizzi (2), A. L´Abbate (2, 3), M. G. Trivella (2) Methods of Information in Medicine 2009 48 2: 113-122 http://dx.doi.org/10.3414/ME0539 | ||
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