HELLP syndrome with fetal growth retardation in a woman homozygous for the prothrombin gene variant 20210A

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2005: 93/4 (Apr) pp. 625-798
Pages: 787-788

HELLP syndrome with fetal growth retardation in a woman homozygous for the prothrombin gene variant 20210A

Georg Moessmer 1, Burkhardt Müller 1, Martin Kolben 2, Manfred Schmitt 2, Karl Theodor Maria Schneider 2, Almut Artmann 2
1 Institute for Clinical Chemistry, 2 Department of Obstetrics and Gynaecology, Technische Universität München, Klinikum rechts der Isar, München, Germany

Summary

A 31-year-old primigravida at 24 2/7 weeks of gestation presented with a 2-day history of diarrhoea and vomiting. On admission, her blood pressure was 160/100 mm Hg, increased for the first time during her pregnancy, but she had no further symptoms of preeclampsia such as proteinuria, oedema, headache, visual disturbance, hyperreflexia or right upper quadrant pain, and no personal or family history of chronic hypertension, renal disease or thromboembolic events. Laboratory findings were normal. Ultrasonography showed a reduced amniotic fluid index of 10 and a growth retarded fetus (below the tenth percentile for the expected weight). Doppler ultrasonography revealed an increased vascular resistance in the uterine arteries and . . .

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