1Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane Queensland, Australia; 2The University of Queensland Centre for Clinical Research, Brisbane Queensland, Australia; 3Centre for Integrative Clinical and Molecular Medicine, School of Medicine, Southern Region, Faculty of Health Sciences, University of Queensland, Brisbane Queensland, Australia.

University of Glasgow, Cardiovascular Science, Glasgow, Scotland, UK

Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

Division of Cardiology, Maggiore della Carità Hospital, Eastern Piedmont University A. Avogadro, Novara, Italy

1Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore; 2Department of Biochemistry, Virginia Commonwealth University Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

1Instituto Venezolano de Investigaciones Científicas, Laboratorio de Hemostasia y Genética Vascular, Centro de Biofísica y Bioquímica, Caracas, Venezuela; 2University Hospital Jena, Research Unit "Pharmacological Haemostaseology", Jena, Germany

1Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; 2Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; 3Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands; 4Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden

1Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore; 2Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia; 3Venom Supplies Pty Ltd, Tanunda, South Australia, Australia; 4Department of Biochemistry, VCU Medical Center, Virginia Commonwealth University, Richmond, Virginia, USA

1Institute of Haematology and Blood Transfusion, Praha, Czech Republic; 2Department of Cardiology, Motol University Hospital, Praha, Czech Republic; 32nd Department of Internal Medicine, University Hospital of Plzen, Plzen, Czech Republic; 4Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Praha, Czech Republic

1The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel; 2Department of Urology, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel; 3 Department of Otolaryngology, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel; 4Department of Surgery, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel

1Centre Hospitalier Universitaire, Vascular Medicine Unit, Montpellier, France; 2Centre Hospitalier Universitaire, Vascular Medicine Unit, Amiens, France; 3Amiens University Hospital, Vascular Medicine Unit, ThEMAS TIMC UMR CNRS 5525 UJF, Grenoble, France; 4Clinical Investigation Centre, Centre Hospitalier Universitaire, Grenoble, France; 5Division of Angiology and Haemostasis, Geneva University Hospital, Geneva, Switzerland; 6Sanofi-Aventis, Paris, France; 7Vascular Medicine Office, Montluçon, France; 8Laboratory of Hematology, Centre Hospitalier Universitaire de Nîmes, Nîmes, France; 9OPTIMEV Investigator list available online at http://www.thrombosis-online.com

1Department of Clinical Medicine, Insubria University, Italy; 2Clinical Pharmacy Anticoagulation Service, Kaiser Permanente, Denver, Colorado, USA; 3Thrombosis/Haemostasis and Haematology Unit, University Hospital of Palermo, Italy; 4University of New Mexico School of Medicine, Albuquerque, New Mexico, USA; 5Department of Medicine, McMaster University, Hamilton, Ontario, Canada

1Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachussetts, USA; 2Department of Pharmacy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachussetts, USA; 3Center for Outcomes Research, University of Massachusetts Medical School, Worcester, Massachussetts, USA

1Servicio Hemoterapia-Hemostasia, Hospital Clinic, CDB, IDIBAPS, UB, Barcelona, Spain; 2Instituto Clínic de Psiquiatría, Hospital Clinic, ICN, Barcelona, Spain

1Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Wuerzburg, Germany; 2Institute of Cell Biology, University of Konstanz, Konstanz, Germany; 3Department of Bioanalytics, ISAS Institute for Analytical Sciences, Bunsen, Dortmund, Germany; 4Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, St. Petersburg, Russia

1Section of Thrombosis Research Department of Medicine, Baylor College of Medicine, Houston, Texas, USA; 2Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA; 3Puget Sound Blood Center, Seattle, Washington, USA

HeartDrug™ Research Laboratories, Johns Hopkins University, Baltimore, Maryland, USA

1Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria; 2Clinical Department for Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria; 3Ludwig Boltzmann Institute for Clinical and Experimental Oncology, Vienna, Austria; 4Present address: Austrian Science Foundation, Vienna, Austria

1Institute of Medicine, University of Bergen, Bergen, Norway; 2Department of Medicine, Stavanger University Hospital, Stavanger, Norway; 3Department of Cardiology, Volvat Medical Center, Oslo, Norway; 4Sigma Statistical Services, Balmullo, UK; 5Perseus Proteomics Inc., Tokyo, Japan; *Current affiliation: Novartis Pharma K.K., Tokyo, Japan

1Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria; 2Section of Clinical Biometrics, Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Vienna, Austria; 3Department of Internal Medicine I, Division of Cancer Research, Medical University of Vienna, Vienna, Austria; 4Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria