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The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids
Timothy R. Rudd1*; Mark A. Skidmore1*; Scott E.Guimond1; Joseph Holman1; Jeremy E. Turnbull1; Robert M. Lauder2; David G. Fernig1; Edwin A. Yates1
1School of Biological Sciences, University of Liverpool, Liverpool, UK; 2School of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Bailrigg, Lancaster, UK
Summary
Summary The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.
Keywords
Quality Control, low-molecular-weight heparin, heparinoids, Circular dichroism, principal component analysis
DOI
http://dx.doi.org/10.1160/TH08-12-0797You may also be interested in...
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