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The contribution of systems biology and reverse genetics to the understanding of Kaposi’s sarcoma-associated herpesvirus pathogenesis in endothelial cells
Michael Stürzl1; Andreas Konrad1; Khaled R. Alkharsah2; Ramona Jochmann1; Mathias Thurau1; Gaby Marquardt1; Thomas F. Schulz2
1Division of Molecular and Experimental Surgery, Department of Surgery, University of Erlangen-Nuremberg, Erlangen, Germany; 2Department of Virology, Medical School Hannover, Hannover, Germany
Summary
Kaposi’s sarcoma-associated herpesvirus (KSHV) / human herpesvirus- 8 is the causative agent of the endothelial cell-derived tumour Kaposi’s sarcoma. Herpesviruses possess large complex genomes which provide many options to regulate cellular physiology during the viral life cycle and in the course of tumourigenicity. Novel techniques of systems biology and reverse genetics are increasingly applied to dissect the complex interaction of KSHV with endothelial cells. This review will outline novel results and pitfalls of these technologies in the elucidation of KSHV pathogenicity.
Keywords
angiogenesis, interferon, apoptosis, endothelial cells, NF-kappaB
DOI
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