Endothelium, venous thromboembolism and ischaemic cardiovascular events

Journal:Thrombosis and Haemostasis
ISSN:0340-6245
DOI:http://dx.doi.org/10.1160/TH09-08-0562
Issue:2010: 103/1 (Jan) pp. 1–249
Pages:56-61

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Endothelium, venous thromboembolism and ischaemic cardiovascular events

P. Gresele (1), S. Momi (1), R. Migliacci (2)
(1) Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy; (2) Division of Internal Medicine, Ospedale della Valdichiana“S.Margherita”, Cortona, Italy

Summary

The association between venous thromboembolism and arterial thrombosis has emerged as consistent clinical observation in the last few years. While several experimental, epidemiological and pharmacologic studies support this association, the initial pathophysiological mechanism linking these two clinical conditions remains to be established. This review discusses the pathophysiological bases and a number of experimental and clinical observations suggesting that the common link between venous thromboembolism and arterial thrombosis is represented by a dysfunctional endothelium.

Keywords

Venous thrombosis, endothelial cells, Arterial thrombosis, atherothrombosis, nitric oxide/NO

DOI

http://dx.doi.org/10.1160/TH09-08-0562
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