A. P. Owens III (1), N. Mackman (1)
(1) Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Thrombosis, or complications from thrombosis, currently occupies the top three positions in the cardiovascular causes of morbidity and mortality in the developed world. There are a limited number of safe and effective drugs to prevent and treat thrombosis. Animal models of thrombosis are necessary to better understand the complex components and interactions involved in the formation of a clot. Tissue factor (TF) is required for the initiation of blood coagulation and likely plays a key role in both arterial and venous thrombosis. Understanding the role of TF in thrombosis may permit the development of new antithrombotic drugs. This review will focus on the role of TF in in vivo models of thrombosis.
thrombosis, Venous thrombosis, Animal models, Arterial thrombosis, tissue factor / factor VII
J.-a. Jiao (1), A. B. Kelly (2), U. M. Marzec (2), E. Nieves (1), J. Acevedo (1), M. Burkhardt (1), A. Edwards (1), X.-y. Zhu (1, 3), P.-A. Chavaillaz (1, 3), A. Wong (1), J. L. Wong (1), J. O. Egan (1, 3), D. Taylor (1, 3), P. R. Rhode (1, 3), H. C. Wong (1, 3)
Thromb Haemost 2010 103 1: 224-233
Sanjiv Baxi1, David L. Crandall3, Thomas R. Meier*,1,2, Shirley Wrobleski1, Angela Hawley1, Diana Farris1, Hassan Elokdah4†, Robert Sigler5, Robert G. Schaub**, 3, Thomas Wakefield1, Daniel Myers1, 2
Thromb Haemost 2008 99 4: 749-758
Nadine S. Gibson1, Maaike Sohne1, Marieke J. H. A. Kruip2, Lidwine W. Tick3, Victor E. Gerdes1, Patrick M. Bossuyt4, Philip S. Wells5, Harry R. Buller1 on behalf of the Christopher study investigators
Thromb Haemost 2008 99 1: 229-234
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