Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1

Journal:Thrombosis and Haemostasis
ISSN:0340-6245
DOI:http://dx.doi.org/10.1160/TH09-12-0814
Issue:2010: 104/3 (Sep) pp. 421–653
Pages:464-470

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Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1

W. L. Lau (1), M. H. Festing (2), C. M. Giachelli (2)

(1) Nephrology, University of Washington, Seattle, Washington, USA; (2) Bioengineering, University of Washington, Seattle, Washington, USA

Summary

Elevated serum phosphate is a risk factor for vascular calcification and cardiovascular events in kidney disease as well as in the general population. Elevated phosphate levels drive vascular calcification, in part, by regulating vascular smooth muscle cell (VSMC) gene expression, function, and fate. The type III sodium-dependent phosphate co-transporter, PiT-1, is necessary for phosphate-induced VSMC osteochondrogenic phenotype change and calcification, and has recently been shown to have unexpected functions in cell proliferation and embryonic development.

Keywords

phosphate, vascular calcification, PiT-1, kidney disease

DOI

http://dx.doi.org/10.1160/TH09-12-0814
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