Anzeige
Anzeige
Anzeige

Platelets, inflammation and tissue regeneration

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Contemporary issues in atherothrombosis

DOI: http://dx.doi.org/10.1160/THS10-11-0720
Issue: 2011: 105/Supplement 1
Pages: S13-S33

Platelets, inflammation and tissue regeneration

A. T. Nurden (1)

(1) Centre de Référence des Pathologies Plaquettaires, Plateforme Technologique et d'Innovation Biomédicale, Hôpital Xavier Arnozan, Pessac, France

Summary

Blood platelets have long been recognised to bring about primary haemostasis with deficiencies in platelet production and function manifesting in bleeding while upregulated function favourises arterial thrombosis. Yet increasing evidence indicates that platelets fulfil a much wider role in health and disease. First, they store and release a wide range of biologically active substances including the panoply of growth factors, chemokines and cytokines released from a-granules. Membrane budding gives rise to microparticles (MPs), another active participant within the blood stream. Platelets are essential for the innate immune response and combat infection (viruses, bacteria, micro-organisms). They help maintain and modulate inflammation and are a major source of pro-inflammatory molecules (e.g. P-selectin, tissue factor, CD40L, metalloproteinases). As well as promoting coagulation, they are active in fibrinolysis; wound healing, angiogenesis and bone formation as well as in maternal tissue and foetal vascular remodelling. Activated platelets and MPs intervene in the propagation of major diseases. They are major players in atherosclerosis and related diseases, pathologies of the central nervous system (Alzheimers disease, multiple sclerosis), cancer and tumour growth. They participate in other tissue-related acquired pathologies such as skin diseases and allergy, rheumatoid arthritis, liver disease; while, paradoxically, autologous platelet-rich plasma and platelet releasate are being used as an aid to promote tissue repair and cellular growth. The above mentioned roles of platelets are now discussed.

Keywords

angiogenesis, wound healing, inflammation, Platelets, immunity, acquired diseases with platelet involvement

DOI

http://dx.doi.org/10.1160/THS10-11-0720

You may also be interested in...

1.

Paolo Zamboni, Donato Gemmati

Thromb Haemost 2007 98 1: 131-137

http://dx.doi.org/10.1160/TH06-11-0625

2.

C. Reinhardt

Hämostaseologie 2007 27 1: 55-58

3.

Jinan Li,1 Per-Olof Eriksson,2 Annika Hansson,2 Sten Hellström2, Tor Ny1*

Thromb Haemost 2006 96 4: 512-519

http://dx.doi.org/10.1160/TH06-03-0168



Thrombosis News

Mobile technology identifies people with unknown atrial fibrillation at high risk of stroke – article published in Thrombosis and Haemostasis

The article “Feasibility and cost effectiveness of stroke prevention through community screening...

TH 111.4

The April 2014 TH 111.4 issue of Thrombosis and Haemostasis is a Theme Issue by Guest Editor B....

TH 111.3

Women with atrial fibrillation have a much higher risk for thromboembolic stroke than men suffering...