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Glycoprotein Ibα and von Willebrand factor in primary platelet adhesion and thrombus formation: Lessons from mutant mice
Wolfgang Bergmeier1, Anil K. Chauhan2,3, Denisa D. Wagner2,3
1Cardeza Foundation for Hematologic Research and Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; 2Immune Disease Institute and 3Department of Pathology, Harvard Medical School, Boston, Massachussetts, USA
Summary
The von Willebrand factor (VWF) receptor complex, glycoprotein (GP)Ib-V-IX, and its main ligand VWF play a key role in the adhesion process of platelets to sites of vascular injury. Recent studies in mutant mice have shed new light on the importance of either molecule for the development of arterial and venous thrombosis. In this review, we summarize the most important aspects from these studies.
Keywords
thrombosis, vonWillebrand factor, mice, glycoprotein, mutant
DOI
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