The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions

Journal:Thrombosis and Haemostasis
ISSN:0340-6245
DOI:http://dx.doi.org/10.1160/TH08-05-0300
Issue:2009: 101/2 (Feb) pp. 217-412
Pages:284-289

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The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions

Domenico Del Principe1; Gianluca Frega1; Isabella Savini2; M. Valeria Catani2; Antonello Rossi2; Luciana Avigliano2
1Department of Public Health and Cell Biology, University of Rome ‘Tor Vergata’, Italy; 2Department of Experimental Medicine & Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy

Summary

The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet crosstalk.

Keywords

Platelets, NAD(P)H oxidase, plasma membrane redox system, ubiquinone, antioxidant vitamins

DOI

http://dx.doi.org/10.1160/TH08-05-0300
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