Haemostasis and pregnancy

Journal:Thrombosis and Haemostasis
ISSN:0340-6245
DOI:http://dx.doi.org/10.1160/TH05-11-0753
Issue:2006: 95/3 (Mar) pp. 397-590
Pages:401-413

Haemostasis and pregnancy

Massimo Franchini
Servizio di Immunoematologia e Trasfusione – Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy

Summary

Normal pregnancy is associated with profound alterations in thecoagulation and fibrinolytic systems. While these physiologicalprocoagulant changes are aimed to minimise intrapartum bloodloss, they do increase the risk of thromboembolism during pregnancyand the post-partum period. In contrast and more rarely, haemorrhage due to an underlying inherited or acquired bleedingdisorder may occur and complicate a pregnancy. Based on ananalysis of the literature data, this review presents an overviewof the main thrombotic and haemorrhagic disorders complicatingpregnancy.

Keywords

thrombophilia, pregnancy, Haemostasis, bleeding

DOI

http://dx.doi.org/10.1160/TH05-11-0753

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