Summary

90 patients with acute stroke and a concomitant cardiac embolismsource or a symptomatic high-grade stenosis of an extra- orintracranial vessel received in a mulitcenter, randomized,controlled study either Enoxaparin 1 mg/kg BW s.c. b.i.d. or i.v.heparin aPTT-adjusted daily for 8 +/- 2 days as secondary prophylaxis.There were no significant differences between the two groups regarding cerebral and systemic embolic events, bleedingcomplications, length of hospital stay, number of diagnosticand therapeutic measures and outcome after three months.This suggests that Enoxaparin, which is easier to administer andmonitor, is a safe drug in patients with acute cerebral events.