Neurovascular Research Laboratory, Neurovascular Unit. Neurology Service, Departamento de medicina, Vall d’Hebron Hospital, Universitat
Autonoma de Barcelona, Barcelona, Spain

1Department of Cardiothoracic Anesthesiology and Critical Care, Emory University School of Medicine, Emory Healthcare, Atlanta, Georgia,
USA; 2Southampton Hospital, Southampton, UK; 3Department of Anesthesiology, SUNY Upstate Medical University, Syracuse, New York,
USA; 4Department of Cardiothoracic Surgery, Rigshospitalet, University of Copenhagen, Denmark; 5Novo Nordisk A/S, Bagsvaerd, Denmark;
6Novo Nordisk, Princeton, NJ, USA

1William Harvey Research Institute, Barts & the London School of Medicine & Dentistry, Queen Mary University of London, London, UK;
2Ernest Cooke Clinical Microvascular Unit, St Bartholomew's Hospital, Barts & The London NHS Trust, London, UK; 3Cardiothoracic
Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, London, UK

1University Department of Anesthesiology and Pain Therapy, University Hospital of Bern, Bern, Switzerland; 2NHMRC Clinical Trials Centre,
University of Sydney, Sydney, Australia; 3Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney,
Australia; 4University Department of Hematology, University Hospital of Bern, Bern, Switzerland

1Clinical Research Center, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary; 2Haemostasis, Thrombosis and
Vascular Biology Research Group of the Hungarian Academy of Sciences, Debrecen, Hungary

1Department of Clinical Sciences, Danderyds Hospital Karolinska Institutet, Stockholm, Sweden; 2Department of Molecular Medicine and
Surgery, Karolinska Institutet, Stockholm, Sweden; 3Biopharmaceuticals Research Unit, Novo Nordisk A/S, Novo Nordisk Park, Måløv,
Denmark; 4Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; 5University of Lund, Sweden

1UMR_S 949 INSERM-Université de Strasbourg, Etablissement Français du Sang-Alsace, Strasbourg Cedex, France; 2Institute of Clinical
Biochemistry and Pathobiochemistry, University of Würzburg, Würzburg, Germany

1Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, Geneva,
Switzerland; 2Division of vascular medicine, Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland