Within this issue of VCOT 6/2013, the topic of osteoarthrisis is looked at, both with the Guest Editorial by Matthew Stewart and in the Original Research performed by Pigott et al. Most currently available therapies for osteoarthritis modulate the clinical signs of arthritis but do little to arrest or reverse the disease process. There are however several biological and gene-based strategies which show promise. The article by Pigott et al. look at one critical aspect of cell-based therapies – that of whether or not stem cell therapy requires autologous cell stocks or if instead one can use pre-prepared allogeneic or xenogeneic cell sources. For more information see the Guest Editorial as well as the article by Pigott et al.