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Late effects on haemostasis after haematopoietic stem cell transplantation

Journal:Hämostaseologie
ISSN:0720-9355
DOI:http://dx.doi.org/10.5482/ha-1184
Issue:Issues of 2012 (Vol. 32): Issue 1 2012 (1-86)
Pages:63-66

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Late effects on haemostasis after haematopoietic stem cell transplantation

G. Stussi (1), D. A. Tsakiris (2)

(1) Division of Haematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; (2) Division of Haematology, Department of internal medicine, University Hospital Basel, Switzerland

Summary

Allogeneic and autologous hematopoietic stem cell transplantations are important therapeutic options for patients with hematologic disorders. Hemostatic complications are frequent after hematopoietic stem cell transplantation with a considerable morbidity and mortality. The incidence of bleedings and thrombosis is highest in the first few weeks after transplantation, but may also occur later. However, beyond the first year of transplantation only limited data are available. In long-term survivors the risk for premature atherosclerosis increases over time after allogeneic hematopoietic stem cell transplantation and it is higher than in the age-adjusted general population and in recipients of autologous transplantation.

Keywords

Atherosclerosis, venous thromboembolism, Haemostasis, GvHD

DOI

http://dx.doi.org/10.5482/ha-1184
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