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Effekte von Teriparatid auf knochenhistologische Parameter bei einer Patientin mit adynamer renaler Knochenerkrankung und Wirbelkörperfrakturen

Journal: Osteologie
ISSN: 1019-1291
Topic:

Kalzium-Phosphat-Stoffwechsel und Knochen

Issue: Issues of 2017 (Vol. 26): HeIssue 3 2017 (131-191)
Pages: 153-156

Effekte von Teriparatid auf knochenhistologische Parameter bei einer Patientin mit adynamer renaler Knochenerkrankung und Wirbelkörperfrakturen

Effects of teriparatide on bone histology in a patient with adynamic bone disease and vertebral fractures

G. Lehmann, A. Pfeil, G. Wolf

Keywords

teriparatide, Bone remodeling, adynamic renal bone disease

Summary

Human recombinant teriparatide (human parathyroid hormone 1–34 of recombinant DNA origin) is an osteoanabolic acting peptide hormone. Teriparatide treatment results in activation of bone remodeling and increases bone mineral density. Effects on bone structure, bone mass and bone quality have been demonstrated in histomorphometric studies. Once-daily subcutaneous administration was shown to be effective in reduction of fracture risk in postmeopausal osteoporosis, in idiopathic or hypogonadal osteoporosis in men and in glucocorticoid induced osteoporosis. There are only limited data about teriparatide effects in patients with elevated PTH levels due to renal insufficiency. We report a 60 year old woman with CKD-MBD stage 4 and multiple vertebral fractures with adynamic renal bone disease due to bisphosphonate and denosumab therapy. Histomorphometric analysis of bone biopsies taken before and after treatment with teriparatide for 20 months demonstrate a considerable increase of mineralized bone volume and also stimulated bone resorption.

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