C. E. Mahan (1), M. T. Holdsworth (1), S. M. Welch (2), M. Borrego (1), A. C. Spyropoulos (3)
(1) University of New Mexico College of Pharmacy, Albuquerque, New Mexico, USA; (2) Cardinal Health Pharmacy Solutions, Lovelace Medical Center, Albuquerque, New Mexico, USA; (3) Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Preventable venous thromboembolism (VTE) and “appropriate” type, dose, and duration of prophylaxis are emerging concepts. Contemporary definitions by key quality organisations, including the World Health Organization, have shifted towards “preventable” VTE being considered an adverse event or adverse drug event. A decision tree and cost model were developed to estimate the United States health care costs for total deep-vein thrombosis (DVT), total hospital-acquired DVT, and total “preventable” DVT. Annual cost ranges were obtained in 2010 US dollars for total ($7.5 to $39.5 billion), hospital-acquired ($5 to $26.5 billion), and preventable ($2.5 to $19.5 billion) DVT costs. When the sensitivity analysis was applied – taking into consideration higher incidence rates and costs – annual US total, hospital-acquired, and “preventable” DVT costs ranged from $9.8 to $52 billion, $6.8 to $36 billion, and $3.4 to $27 billion, respectively.
Deep-vein thrombosis, Adverse event, Adverse drug event, cost model, preventable
C. E. Mahan (1), M. E. Borrego (2), A. L. Woersching (2), R. Federici (3), R. Downey (3), J. Tiongson (3), M. C. Bieniarz (3), B. J. Cavanaugh (3), A. C. Spyropoulos (4)
Thromb Haemost 2012 108 2: 291-302
W. Blättler 1 , H. E. Gerlach2
Phlebologie 2005 34 3: 146-156
Alexander T. Cohen1, Giancarlo Agnelli2, Frederick A. Anderson3, Juan I. Arcelus4, David Bergqvist5, Josef G. Brecht6, Ian A. Greer7, John A. Heit8, Julia L. Hutchinson9, Ajay K. Kakkar10, Dominique Mottier11, Emmanuel Oger11, Meyer-Michel Samama12, Michael Spannagl13 for the VTE Impact Assessment Group in Europe (VITAE)
Thromb Haemost 2007 98 4: 756-764
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