D. Landi (1), M. G. Beckman (2), N. R. Shah (1, 3), P. Bockenstedt (4), A. M. Grant (2), J. A. Heit (5), N. S. Key (6), R. Kulkarni (7), M. Manco-Johnson (8), S. Moll (6), C. S. Philipp (9), J. C. Andersen (10), T. L. Ortel (3)
(1) Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA; (2) Centers for Disease Control and Prevention, Atlanta, Georgia, USA; (3) Division ofHematology, Duke University Medical Center, Durham, North Carolina, USA; (4) Hematology Oncology, University of Michigan, Ann Arbor, Michigan, USA; (5) Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA; (6) University of North Carolina, Chapel Hill, North Carolina, USA; (7) Pediatrics Human Dev., Michigan State University, East Lansing, Michigan, USA; (8) University of Colorado and Children’sHospital, Aurora, Colorado, USA; (9) University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA; (10) Wayne State University, Karmanos Cancer Institute, Detroit, Michigan, USA
The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the setting of known disease might have prognostic implications different from LE DVT/PE. This study describes clinical presentations of abdominal VT compared to LE DVT/PE in adults and children. We analysed prospectively-collected data from consecutive consenting patients enrolled in one of seven Centers for Disease Control and Prevention (CDC) funded Thrombosis and Hemostasis Network Centers from August 2003 to April 2011 to compare the demographic and clinical characteristics of adults and children with abdominal VT. Both adults and children with abdominal VT tended to be younger and have a lower body mass index (BMI) than those with LE DVT/PE. Of patients with abdominal VT, children were more likely to have inferior vena cava (IVC) thrombosis than adults. For adults with venous thromboembolism (VTE), relatively more women had abdominal VT than LE DVT/PE, while the proportions with LE DVT/PE and abdominal VT by sex were similar in children. Children with abdominal VT were more likely to have diagnosed inherited thrombophilia, while trauma was more common in children with LE DVT/PE. In conclusion, both children and adults with abdominal VT were younger with a lower BMI than those with LE DVT/PE. Significant differences exist between children and adults in respect to abdominal VT compared to LE DVT/PE.
Paediatrics, Deep venous thrombosis, venous thromboembolism, abdominal vein thrombosis
H. Leon Daneschvar1, Ali Seddighzadeh1, Gregory Piazza2, Samuel Z. Goldhaber1
Thromb Haemost 2008 99 6: 1035-1039
Cihan Ay1,*, Lea V. Jungbauer2,*, Alexandra Kaider3, Silvia Koder1, Simon Panzer4, Ingrid Pabinger1, Christine Mannhalter2
Thromb Haemost 2008 99 5: 899-904
Jurga Adomaityte, Maria Farooq, Rehan Qayyum
Thromb Haemost 2008 99 2: 338-342
Patients receiving oral anticoagulants should be carefully managed to minimize the risk of bleeding...
Acquired haemophilia A (AHA) is a rare but often severe bleeding disorder caused by ...
Section III " Vitamin K antagonists in heart disease: Current status and perspectives" of...