Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2006: 96/6 (Dec) pp. 697-863
Pages: 744-749

Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden

Francis Couturaud 1, Clive Kearon 4, Christophe Leroyer 1, Bernard Mercier 2, Jean Francois Abgrall 1, Grégoire Le Gal 1, Karine Lacut 1, Emmanuel Oger 1, Luc Bressollette 1, Claude Ferec 1, Michel Lamure 3, Dominique Mottier 1 for the GETBO
1 G.E.T.B.O. (Groupe d’Etude de la Thrombose de Bretagne Occidentale), EA 3878, Dept of Internal Medicine and Chest Diseases, Brest, France; 2 Transfusion Centre, Brest, France; 3 Statistical Dept, Lyon, France; 4 McMaster University and the Henderson


The factor V Leiden (FVL) mutation, a genetic abnormality with an autosomal mode of inheritance, is associated with an increased risk of venous thromboembolism (VTE). We aimed to determine the annual incidence of VTE in first-degree relatives of patients with VTE and FVL and to identify factors in patients and the relatives that influence this incidence. In this retrospective and prospective cohort study, the incidence of objectively diagnosed first episodes of VTE was assessed in 553 first-degree relatives of 161 patients with acute VTE and FVL.The annual incidence of VTE was 0.43% (95% CI, 0.3 to 0.56) with FVL and 0.17 % (95% CI,0.07 to 0.27) without FVL (relative risk of 2.5,95% CI, 1.3 to 4.7). A majority (70%) of episodes ofVTE were provoked, and this proportion was similar with and without FVL.A larger proportion of VTE was provoked in women (83%) that in men (33%),with the difference accounted for by pregnancy and use of oral contraceptives.The proportion of pregnancies complicated by VTE was 3.9% (95% CI, 2.0–5.8) with FVL and 1.4% (95% CI, 0.04–2.7) without FVL. FVL is associated with a two- to three-fold increase in VTE in first-degree relatives of patients with VTE. No subgroup of relatives was identified who require more than routine prophylaxis because of a particularly high risk of VTE.


Venous thrombosis, factor V Leiden, Familial thrombosis


You may also be interested in...


Elena Rossi, Tommaso Za, Angela Ciminello, Giuseppe Leone, Valerio De Stefano

Thromb Haemost 2008 99 6: 1030-1034


Felipe Guerrero1 , Catherine Arnaud2 , Francoise Nguyen1 , Bernard Boneu 1 , Pierre Sié1

Thromb Haemost 2006 95 4: 728-734


B. Zöller (1), X. Li (1), H. Ohlsson (1), J. Sundquist (1, 2), K. Sundquist (1, 2)

Thromb Haemost 2013 110 6: 1164-1171

Thrombosis News

Mobile technology identifies people with unknown atrial fibrillation at high risk of stroke – article published in Thrombosis and Haemostasis

The article “Feasibility and cost effectiveness of stroke prevention through community screening...

TH 111.4

The April 2014 TH 111.4 issue of Thrombosis and Haemostasis is a Theme Issue by Guest Editor B....

TH 111.3

Women with atrial fibrillation have a much higher risk for thromboembolic stroke than men suffering...