Soluble E-selectin in cardiovascular disease and its risk factors A review of the literature
Vanessa Roldán (1, 2) , Francisco Marín (1, 3) , Gregory Y. H. Lip (1) , Andrew D. Blann (1)
(1) Haemostasis,Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK (2) Hematology Unit, Hospital San Vicente, Spain (3) Cardiology Unit, Hospital General Alicante, Spain
Summary The initial steps in the pathogenesis of atherosclerosis involvechanges to the vascular endothelium, which produces numer-oussubstances involved in the regulation and maintenance ofvascular integrity and the homeostasis of the coagulation/fibri-nolysissystem. A further change in endothelial physiology is anincrease in the surface expression of cell adhesion molecules,such as E-selectin, which regulate adhesive interactionsbetween certain blood cells and endothelium. As E-selectin isonly expressed on activated endothelium, it therefore provides an opportunity to study pathophysiological aspects of this cellin cardiovascular and other disease. However, a soluble form ofE selectin (i.e. sE-selectin) can be found in the plasma. Thisreview will focus on sE-selectin, and its potential role in thepathogenesis of cardiovascular disease as raised levels havebeen found in hypertension, diabetes and hyperlipidemia,although its association in established atherosclerosis diseaseand its value as a prognostic factor is more controversial.