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Diurnal Variation in PAI-1 Activity Predominantly Confined to the 4G-allele of the PAI-1 Gene

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2002: 88/5 (Nov) pp.703-887
Pages: 794-798
Ahead of Print: ###MANUSCRIPT_aheadofprint###

Diurnal Variation in PAI-1 Activity Predominantly Confined to the 4G-allele of the PAI-1 Gene

Tiny Hoekstra 1 , Johanna M. Geleijnse 1 , Evert G. Schouten 1 , Cornelis Kluft 2
1 Division of Human Nutrition & Epidemiology, Wageningen University, Wageningen, The Netherlands; 2 Gaubius Laboratory, TNO-PG, Leiden, The Netherlands

Summary

We examined the diurnal pattern in Plasminogen Activator Inhibitor- type 1 (PAI-1) activity and Plasminogen activator (t-PA) in relation to the 4G/5G-polymorphism in the promoter of the PAI-1 gene. The analyses were performed in the Arnhem Elderly Study, a population-based study of 598 elderly. A single blood sample was drawn and the time of blood sampling was recorded (between 8 a. m. and 5.30 p. m.). Plasma PAI-1 activity was strongly associated with time of blood sampling, showing the highest values in the early morning. The diurnal pattern was clearly present in the 4G/4G (n = 184) and 4G/5G (n = 275) genotypes, but not in the 5G/5G-genotype (n = 139). T-PA antigen showed a weak diurnal variation, which did not differ across the variants of the 4G/5G-polymorphism. Our findings raise the hypothesis that 5G-homozygotic persons may be relatively protected from diurnal variation in the occurrence of coronary events.

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