Advertisement
Advertisement
Advertisement

Combined Effect of Factor V Leiden and Prothrombin 20210A on the Risk of Venous Thromboembolism - Pooled Analysis of 8 Case-control Studies Including 2310 Cases and 3204 Controls

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2001: 86/3 (Sept) pp.728-938
Pages: 809-816
Ahead of Print: ###MANUSCRIPT_aheadofprint###

Combined Effect of Factor V Leiden and Prothrombin 20210A on the Risk of Venous Thromboembolism - Pooled Analysis of 8 Case-control Studies Including 2310 Cases and 3204 Controls

Joseph Emmerich, Frits R. Rosendaal, Marco Cattaneo, Maurizio Margaglione, Valerio De Stefano, Tony Cumming, Valder Arruda, Andreas Hillarp, Jean-Luc Reny, for the study group for pooled-analysis in venous thromboembolism*
Paris: J. Emmerich, J. L. Reny, E. Arnaud, M. Alhenc-Gelas [Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire (Centre Claude Bernard) et Laboratoire d’Hémostase, Paris, France]; Leiden: F. R. Rosendaal, T. Koster, J. P. Vandenbroucke, R.

Summary

Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors involved in venous thromboembolism (VTE). The goal of this pooled analysis of 8 case-control studies, comprising a total of 2310 cases and 3204 controls, was to precisely estimate the risk of VTE in patients bearing both mutations (double heterozygotes). Odds ratios for VTE were 4.9 (95% CI; 4.1-5.9) for the factor V Leiden and 3.8 (3.0-4.9) for the factor II G20210A mutation. Fifty-one cases (2.2%) and none of the controls were double heterozygotes. The odds ratio for venous thrombosis in double heterozygotes was 20.0 (11.1-36.1). Twelve percent of patients heterozygous for factor V Leiden were also heterozygous for factor II G20210A and conversely 23% of patients heterozygous for factor II G20210A were also heterozygous for factor V Leiden. Furthermore, in this large population we analyzed the effect of oral contraceptive (OC) in women carrying one of these mutations. Odds ratio for VTE associated with OC was 2.29 (1.72-3.04). In factor V Leiden carriers using OC, the odds ratio for VTE was 10.25 (5.69-18.45). The odds ratio of the association of factor II mutation and OC use was 7.14 (3.39-15.04). Finally, we also confirmed that the frequency of factor V Leiden was lower in patients with pulmonary embolism than in patients with deep vein thrombosis without PE (odds

Thrombosis News

Mobile technology identifies people with unknown atrial fibrillation at high risk of stroke – article published in Thrombosis and Haemostasis

The article “Feasibility and cost effectiveness of stroke prevention through community screening...

TH 111.4

The April 2014 TH 111.4 issue of Thrombosis and Haemostasis is a Theme Issue by Guest Editor B....

TH 111.3

Women with atrial fibrillation have a much higher risk for thromboembolic stroke than men suffering...