Advertisement
Advertisement
Advertisement

Procoagulant Activity and Cytokine Expression in Whole Blood Cultures from Patients with Atherosclerosis Supplemented with Omega-3 Fatty Acids

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 1999: 81/4 (Apr) pp.479-667
Pages: 566-570

Procoagulant Activity and Cytokine Expression in Whole Blood Cultures from Patients with Atherosclerosis Supplemented with Omega-3 Fatty Acids

Ingebjørg Seljeflot, Odd Johansen (1) , Harald Arnesen (1) , Jan-Bertil Eggesbø (2) , Åse-Britt Westvik (2) , Peter Kierulf (2)
From the Research Forum, (1) Dept of Medicine, (2) Research and Development Group, Dept of Clinical Chemistry, Ullevål University Hospital, Oslo, Norway

Summary

Omega-3 fatty acids (n-3 FA) may reduce atherogenesis and thrombosis. We investigated the effects of n-3 FAs on procoagulant activity and cytokine expression in whole blood cultures from patients with atherosclerosis. Eleven of the 23 included patients had received 5.1 g n-3 FA daily for 6 months (group I) whereas 12 patients had been on placebo (group II). All patients were then given 5.1g n-3 FA daily for another 4 weeks. At baseline significantly lower levels of LPS-induced prothrombin fragment 1+2 were found in group I (p = 0.010), this difference being eliminated after 4 weeks. Il-6 and TNF a were significantly higher at baseline in group I and the differences in changes from baseline between the groups were statistically highly significant with increasing values in group II (Il-6 p = 0.001, TNF a p = 0.002). The present results indicate a reduction in pro-thrombotic potential in patients receiving highly concentrated n-3 FA, whereas some proinflammatory responses might be adverse.

Thrombosis News

Mobile technology identifies people with unknown atrial fibrillation at high risk of stroke – article published in Thrombosis and Haemostasis

The article “Feasibility and cost effectiveness of stroke prevention through community screening...

TH 111.4

The April 2014 TH 111.4 issue of Thrombosis and Haemostasis is a Theme Issue by Guest Editor B....

TH 111.3

Women with atrial fibrillation have a much higher risk for thromboembolic stroke than men suffering...