Recurrent Deep Vein Thrombosis and Two Coagulation Factor Gene Mutations: Quo Vadis?
Anthonie W. A. Lensing (1) , Martin H. Prins (2)
From the (1) Centre for Vascular Medicine, and the (2) Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, The Netherlands
Summary In the past decades considerable progress has been made in theunderstanding of inherited and acquired causes of venous thrombosisand their clinical impact (1). Thus, the risk of a first venous thrombosisis approximately 10-fold increased in subjects with deficiency of antithrombin,protein C or S (1, 2), 7-fold increased in patients withcancer (3), or the antiphospholipid antibody syndrome (4, 5), and 3 to5-fold in carriers of the G1691A allele in the coagulation factor V geneand the G20210A allele in the prothrombin gene (6-8). All together,these conditions can be identified in more than 50% of patients with afirst episode of venous thrombosis (1, 2, 8).