Marco Guerrini1; Zachary Shriver2; Antonella Bisio1; Annamaria Naggi1; Benito Casu1; Ram Sasisekharan2; Giangiacomo Torri1
1Institute for Chemical and Biochemical Research “G. Ronzoni”, Milan, Italy; 2Harvard-MIT Division of Health Sciences & Technology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Recently, certain batches of heparin have been associated with an acute, rapid onset of serious side-effects indicative of allergictype reactions. These reports generated significant concern regarding the possible presence of a dangerous contaminant within heparin and highlighted the need to re-assess the purity criteria of heparin preparations for clinical use. Given the nature of the array of all possible contaminants, traditional screening tests cannot safely differentiate between contaminated and uncontaminated heparin preparations. Mono- and bi-dimensional NMR spectroscopy are powerful techniques that are able to detect and quantify a wide variety of potential sulfated polysaccharide contaminants. As such, these techniques are powerful tools for the analysis and assessment of heparin preparations
Magnetic Resonance, heparins, glycosaminoglycans
R. S. Aquino (1), M. S. Pereira (1), B. C. Vairo (1), L. P. Cinelli (1), G. R. C. Santos (1), R. J. C. Fonseca (1), P. A. S. Mourão (1)
Thromb Haemost 2010 103 5: 1005-1015
Helene Hochart1, P. Vincent Jenkins1,2, Roger J. S. Preston1, Owen P. Smith3, Barry White1,2, James O’Donnell1,2
Thromb Haemost 2008 99 3: 570-575
Bob Lobo1, Christopher Finch1, Amanda Howard1, Sohail Minhas2
Thromb Haemost 2008 99 1: 208-214
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