Articles prepublished January 27, 2012
 |
|
Randomised controlled clinical trial for the use of deracoxib during intense rehabilitation exercises after tibial plateau levelling osteotomy
W. J. Gordon-Evans (1), D. Dunning (2), A. L. Johnson (1), K. E. Knap (1)
(1) University of Illinois, Department of Veterinary Clinical Medicine, Urbana, Illinois, USA; (2) North Carolina State University, Department of Clinical Sciences, Raleigh, North Carolina, USA
Summary
During intense physical exercise, the cyclo-oxygenase-2 (COX-2) pathway is upregulated which contributes to soreness. The aim of this study was to determine if there was a clinical affect of deracoxib (COX-2 selective antagonist) on dogs engaged in intense rehabilitation following tibial plateau levelling osteotomy for cranial cruciate ligament rupture. Our hypothesis was that dogs receiving deracoxib would demonstrate less lameness, better range-of-motion (ROM), and faster muscle mass recovery than the control dogs. Thirty dogs were randomised to the treatment (deracoxib at 1–2 mg/kg once daily by mouth) or control (no treatment) group. Outcomes including gait analysis, thigh circumference, and goniometry, were measured by one investigator, who was masked to group preoperatively, and at the end of each intense rehabilitation week (3, 5, and 7 weeks postoperatively). The only difference between groups for any outcome measure at any time point was a greater preoperative stifle ROM in the group receiving deracoxib (p = 0.04). This study showed that treatment with deracoxib did not provide better outcomes when dogs were subjected to intense rehabilitation after tibial plateau levelling osteotomy. Each patient should be evaluated individually to determine if administration of deracoxib is appropriate.
Keywords
Exercise, non-steroidal anti-inflammatory drugs, TPLO, rehabilitation, NSAID, tibial plateau levelling osteotomy
DOI
http://dx.doi.org/10.3415/VCOT-09-11-0121You may also be interested in...
| 1. | ||
S. Barry (1) VCOT - Veterinary and Comparative Orthopaedics and Traumatology 2010 23 6: 385-392 http://dx.doi.org/10.3415/VCOT-10-01-0017 | ||
| 2. | ||
H. M. Clayton, A. D. White, L. J. Kaiser, S. Nauwelaerts, M. Lavagnino, N. C. Stubbs VCOT - Veterinary and Comparative Orthopaedics and Traumatology 2008 21 3: 211-214 | ||
| 3. | ||
Hans Ruder1, Gisela Offner2 Kinder- und Jugendmedizin 2008 8 5: 294-298 | ||
Articles prepublished November 22, 2011
|
|
Randomised controlled clinical trial for the use of deracoxib during intense rehabilitation exercises after tibial plateau levelling osteotomy
W. J. Gordon-Evans (1), D. Dunning (2), A. L. Johnson (1), K. E. Knap (1)
(1) University of Illinois, Department of Veterinary Clinical Medicine, Urbana, Illinois, USA; (2) North Carolina State University, Department of Clinical Sciences, Raleigh, North Carolina, USA
Summary
During intense physical exercise, the cyclo-oxygenase-2 (COX-2) pathway is upregulated which contributes to soreness. The aim of this study was to determine if there was a clinical affect of deracoxib (COX-2 selective antagonist) on dogs engaged in intense rehabilitation following tibial plateau levelling osteotomy for cranial cruciate ligament rupture. Our hypothesis was that dogs receiving deracoxib would demonstrate less lameness, better range-of-motion (ROM), and faster muscle mass recovery than the control dogs. Thirty dogs were randomised to the treatment (deracoxib at 1–2 mg/kg once daily by mouth) or control (no treatment) group. Outcomes including gait analysis, thigh circumference, and goniometry, were measured by one investigator, who was masked to group preoperatively, and at the end of each intense rehabilitation week (3, 5, and 7 weeks postoperatively). The only difference between groups for any outcome measure at any time point was a greater preoperative stifle ROM in the group receiving deracoxib (p = 0.04). This study showed that treatment with deracoxib did not provide better outcomes when dogs were subjected to intense rehabilitation after tibial plateau levelling osteotomy. Each patient should be evaluated individually to determine if administration of deracoxib is appropriate.
Keywords
Exercise, non-steroidal anti-inflammatory drugs, TPLO, rehabilitation, NSAID, tibial plateau levelling osteotomy
DOI
http://dx.doi.org/10.3415/VCOT-09-11-0121You may also be interested in...
| 1. | ||
S. Barry (1) VCOT - Veterinary and Comparative Orthopaedics and Traumatology 2010 23 6: 385-392 http://dx.doi.org/10.3415/VCOT-10-01-0017 | ||
| 2. | ||
H. M. Clayton, A. D. White, L. J. Kaiser, S. Nauwelaerts, M. Lavagnino, N. C. Stubbs VCOT - Veterinary and Comparative Orthopaedics and Traumatology 2008 21 3: 211-214 | ||
| 3. | ||
Hans Ruder1, Gisela Offner2 Kinder- und Jugendmedizin 2008 8 5: 294-298 | ||
Articles prepublished October 26, 2011
|
|
Randomised controlled clinical trial for the use of deracoxib during intense rehabilitation exercises after tibial plateau levelling osteotomy
W. J. Gordon-Evans (1), D. Dunning (2), A. L. Johnson (1), K. E. Knap (1)
(1) University of Illinois, Department of Veterinary Clinical Medicine, Urbana, Illinois, USA; (2) North Carolina State University, Department of Clinical Sciences, Raleigh, North Carolina, USA
Summary
During intense physical exercise, the cyclo-oxygenase-2 (COX-2) pathway is upregulated which contributes to soreness. The aim of this study was to determine if there was a clinical affect of deracoxib (COX-2 selective antagonist) on dogs engaged in intense rehabilitation following tibial plateau levelling osteotomy for cranial cruciate ligament rupture. Our hypothesis was that dogs receiving deracoxib would demonstrate less lameness, better range-of-motion (ROM), and faster muscle mass recovery than the control dogs. Thirty dogs were randomised to the treatment (deracoxib at 1–2 mg/kg once daily by mouth) or control (no treatment) group. Outcomes including gait analysis, thigh circumference, and goniometry, were measured by one investigator, who was masked to group preoperatively, and at the end of each intense rehabilitation week (3, 5, and 7 weeks postoperatively). The only difference between groups for any outcome measure at any time point was a greater preoperative stifle ROM in the group receiving deracoxib (p = 0.04). This study showed that treatment with deracoxib did not provide better outcomes when dogs were subjected to intense rehabilitation after tibial plateau levelling osteotomy. Each patient should be evaluated individually to determine if administration of deracoxib is appropriate.
Keywords
Exercise, non-steroidal anti-inflammatory drugs, TPLO, rehabilitation, NSAID, tibial plateau levelling osteotomy
DOI
http://dx.doi.org/10.3415/VCOT-09-11-0121You may also be interested in...
| 1. | ||
S. Barry (1) VCOT - Veterinary and Comparative Orthopaedics and Traumatology 2010 23 6: 385-392 http://dx.doi.org/10.3415/VCOT-10-01-0017 | ||
| 2. | ||
H. M. Clayton, A. D. White, L. J. Kaiser, S. Nauwelaerts, M. Lavagnino, N. C. Stubbs VCOT - Veterinary and Comparative Orthopaedics and Traumatology 2008 21 3: 211-214 | ||
| 3. | ||
Hans Ruder1, Gisela Offner2 Kinder- und Jugendmedizin 2008 8 5: 294-298 | ||
Articles
You've 118 Article(s) in your Basket.
VCOT 1/2012
Cranial cruciate ligament rupture is one of the most common conditions affecting the stifle joint...
VCOT 6/2011
TPLO and Implant Removals
VCOT 5/2011
The Importance of Bone Blood Supply