Michael Amling, MD, MBA, ML

Professor and Chair
Department of Osteology and Biomechanics (IOBM)
University Medical Center Hamburg-Eppendorf

Address:
Campus:
Martinistrasse 52, 20246 Hamburg, Germany

Outpatient Clinic:
Lottestrasse 59, 22529 Hamburg, Germany

phone: +49 (0)40-7410-56083, fax: +49 (0)40-7410-58010
e-mail: Opens window for sending emailamling(at)uke.de
website: Opens external link in new windowwww.iobm.de



Academic appointments

2013– Board of Directors, Research Center Medical Engineering Hamburg, FMTHH
2010– Professor & Chair, Dept. of Osteology & Biomechanics, Hamburg University
2005– Director, Center of Biomechanics and Skeletal Biology, Hamburg University
2004-2009

Professor of Experimental Trauma Surgery, Hamburg University

2002-2004 Consultant in Trauma Surgery and Associate Professor, Hamburg University
1998-2002Resident in Trauma Surgery, Hamburg University
1997-1998

Resident in Orthopedics, Hamburg University

1995-1997Postdoc, Cell Biology and Orthopedics, Yale University
1992-1995Resident in Pathology, Hamburg University


Education

2005-2008

Executive MBA Health Care Management, EBS, Oestrich-Winkel

1999-2001 Postgraduate studies in Molecular Medicine, ZMNH HH University
1986-1992 Medical-Student


Degrees

2008

MBA, EBS Oestrich-Winkel, International University Schloss Reichartshausen

2003 Habilitation in Trauma Surgery, University Med. Center Hamburg Eppendorf
2002

Board Exam in Surgery

1993

MD, Hamburg University



Awards and Honors

  • Member of the National Academy of Science LEOPOLDINA
  • Harold-Copp-Award 2015
  • Spokesman National Bone Board, since 2014
  • Editor BONE, since 2013
  • DFG Board Member Medicine for Orthopedics and Trauma Surgery, 2008 - 2016
  • Spokesman DFG Research Group 793, 2007–2015
  • Hans-Liniger-Award 2003
  • Dr. Martini-Award 2001
  • Julius-Wolff-Award 1997
  • Julius-Wolff-Award 1996
  •  von Recklinghausen-Award 1994



Selected Publications

Uluçkan Ö, Jimenez M, Karbach S, Jeschke A, Graña O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G, Wagner EF. Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts.
Sci Transl Med. 2016 Mar 16;8(330):330ra37.

Keller J, Catala-Lehnen P, Huebner AK, Jeschke A, Heckt T, Lueth A, Krause M, Koehne T, Albers J, Schulze J, Schilling S, Haberland M, Denninger H, Neven M, Hermans-Borgmeyer I, Streichert T, Breer S, Barvencik F, Levkau B, Rathkolb B, Wolf E, Calzada-Wack J, Neff F, Gailus-Durner V, Fuchs H, de Angelis MH, Klutmann S, Tsourdi E, Hofbauer LC, Kleuser B, Chun J, Schinke T, Amling M. Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.
Nat Commun. 2014 Oct 21;5:5215.

Kollmann K, Pestka JM, Kühn SC, Schöne E, Schweizer M, Karkmann K, Otomo T, Catala-Lehnen P, Failla AV, Marshall RP, Krause M, Santer R, Amling M, Braulke T, Schinke T. Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II.
EMBO Mol Med. 2013 Dec;5(12):1871-86.

Milovanovic P, Zimmermann EA, Hahn M, Djonic D, Püschel K, Djuric M, Amling M, Busse B. Osteocytic canalicular networks: morphological implications for altered mechanosensitivity.
ACS Nano. 2013 Sep 24;7(9):7542-51.

Busse B, Bale HA, Zimmermann EA, Panganiban B, Barth HD, Carriero A, Vettorazzi E, Zustin J, Hahn M, Ager JW 3rd, Püschel K, Amling M, Ritchie RO. Vitamin D deficiency induces early signs of aging in human bone, increasing the risk of fracture.
Sci Transl Med. 2013 Jul 10;5(193):193ra88.

Keupp K, Beleggia F, Kayserili H, Barnes AM, Steiner M, Semler O, Fischer B, Yigit G, Janda CY, Becker J, Breer S, Altunoglu U, Grünhagen J, Krawitz P, Hecht J, Schinke T, Makareeva E, Lausch E, Cankaya T, Caparrós-Martín JA, Lapunzina P, Temtamy S, Aglan M, Zabel B, Eysel P, Koerber F, Leikin S, Garcia KC, Netzer C, Schönau E, Ruiz-Perez VL, Mundlos S, Amling M, Kornak U, Marini J, Wollnik B. Mutations in WNT1 cause different forms of bone fragility.
Am J Hum Genet. 2013 Apr 4;92(4):565-74.

Albers J, Keller J, Baranowsky A, Beil FT, Catala-Lehnen P, Schulze J, Amling M, Schinke T. Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin.
J Cell Biol. 2013 Feb 18;200(4):537-49.

Albers J, Schulze J, Beil FT, Gebauer M, Baranowsky A, Keller J, Marshall RP, Wintges K, Friedrich FW, Priemel M, Schilling AF, Rueger JM, Cornils K, Fehse B, Streichert T, Sauter G, Jakob F, Insogna KL, Pober B, Knobeloch KP, Francke U, Amling M, Schinke T. Control of bone formation by the serpentine receptor Frizzled-9.
J Cell Biol. 2011 Mar 21;192(6):1057-72.

Busse B, Djonic D, Milovanovic P, Hahn M, Püschel K, Ritchie RO, Djuric M, Amling M. Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone.
Aging Cell. 2010 Dec;9(6):1065-75.

Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss MM, Angel PE, Lerner UH, David JP, Reichardt HM, Amling M, Schütz G, Tuckermann JP. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Cell Metab. 2010 Jun 9;11(6):517-31.

Schinke T, Schilling AF, Baranowsky A, Seitz S, Marshall RP, Linn T, Blaeker M, Huebner AK, Schulz A, Simon R, Gebauer M, Priemel M, Kornak U, Perkovic S, Barvencik F, Beil FT, Del Fattore A, Frattini A, Streichert T, Pueschel K, Villa A, Debatin KM, Rueger JM, Teti A, Zustin J, Sauter G, Amling M. Impaired gastric acidification negatively affects calcium homeostasis and bone mass.
Nature Med. 2009 Jun;15(6):674-81.

Bozec A, Bakiri L, Hoebertz A, Eferl R, Schilling AF, Komnenovic V, Scheuch H, Priemel M, Stewart CL, Amling M, Wagner EF. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia.
Nature. 2008 Jul 10;454(7201):221-5.

Schmidt K, Schinke T, Haberland M, Priemel M, Schilling AF, Mueldner C, Rueger JM, Sock E, Wegner M, Amling M. The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation.
J Cell Biol. 2005 Mar 14;168(6):899-910.

A.O. Hoff, P. Catala-Lehnen, P.M. Thomas, M. Priemel, J.M. Rueger, A. Bradley, G.J. Cote, M. Amling, G.F. Gagel. Deletion of the mouse calcitonin gene leads to increased bone formation and protection against bone loss caused by estrogen deficiency.
J Clin Invest 110: 1849-1857, 2002

P. Ducy*, M. Amling*, S. Takeda, M. Priemel, A.F. Schilling, F.T. Beil, J. Shen, C. Vinson, J.M. Rueger, G. Karsenty. Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass. (*Co-First)
Cell 100: 197-207, 2000

M. Amling, L. Neff, M. Priemel, A.F. Schilling, J.M. Rueger, R. Baron. Progressive increase in bone mass and development of odontomas in aging osteopetrotic c-src-deficient mice.
Bone 27: 603-610, 2000

A. Delany*, M. Amling*, M. Priemel, C. Howe, E. Gelke, R. Baron, E. Canalis. Osteonectin-null mice develop severe osteopenia. (*Co-First)
J Clin Invest 15: 915-923, 2000

T. Günther, Z.-F. Chen, J. Kim, M. Priemel, J.M. Rueger, M. Amling, J.M. Moseley, T.J. Martin, D.J. Anderson, G. Karsenty. Genetic ablation of parathyroid glands reveals another source of parathyroid hormone.
Nature 406: 199-203, 2000

G. Sabatakos, N.A. Sims, J. Chen, K. Aoki, M.B. Kelz, M. Amling, Y. Bouali, K. Mukhopadhyay, K. Ford, E.J. Nestler, R. Baron Overexpression of FosB transcription factor(s) increases bone formation and inhibits adipogenesis.
Nature Medicine 6: 985-990, 2000

M. Amling, M. Priemel, T. Holzmann, K. Chapin, J.M. Rueger, R. Baron, M.B. Demay. Rescue of the skeletal phenotype of vitamin D receptor ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses.
Endocrinology 140: 4982-4987, 1999

D. Corral*, M. Amling*, M. Priemel, E. Loyer, S. Fuchs, P. Ducy, R. Baron, G. Karsenty. Dissociation between bone resorption and bone formation in osteopenic transgenic mice. (*Co-First)
Proc Natl Acad Sci USA 95: 13835-13840, 1998

M. Amling, L. Neff, S. Tanaka, D. Inoue, K. Kuida, E. Weir, W.M. Philbrick, A.E. Broadus, R. Baron. Bcl-2 lies down¬stream of parathyroid hormone-related peptide in a signalling pathway that regulates chondrocyte maturation during skeletal development.
J Cell Biol 136: 205-213, 1997

S. Tanaka*, M. Amling*, L. Neff, A. Peyman, E. Uhlmann, J. Levy, R. Baron. c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. (*Co-First)
Nature 383: 528-531, 1996